Botox® vs. Dysport® vs. Xeomin® – What are the Differences?

Blog Feature Image

Frowning, squinting and smiling are expressions we all make every day, and as we age, these facial movements can unfortunately lead to wrinkles over time. Botulinum toxin type A is an injectable neurotoxin which is by far the most popular anti-wrinkle treatment used in the U.S. today. When neurotoxins are injected directly into wrinkles, it blocks muscle nerve impulses and causes them to relax. The result is diminished wrinkles and a more refreshed, youthful appearance.

Botox® and Its Competing Brands

You’ve certainly heard of Botox®, which was the first injectable neurotoxin approved by the FDA in 2002 to treat wrinkles between the eyes. But what many people don’t realize is that Botox® is not a procedure – it’s a brand, and today, there are two other Botox®-like brands available that provide similar but somewhat different benefits. The other two brands are Dysport®, which was FDA approved in 2009, and Xeomin®, which approved for use in the U.S. in 2011.

Multiple studies have shown that all three brands of Botulinum toxin A are effective for reducing wrinkles around the eyes (also known as “crow’s feet”), forehead creases, the glabella (also known as number 11’s between the eyes), and can also be used to treat profuse underarm sweating and migraine headaches. There are, however, some notable differences between these brands.

What are the Differences Between Botox®, Dysport® and Xeomin®?

Botox®, Dysport® and Xeomin® all contain Botulinum toxin A as the same active ingredient and can be used safely on all adult skin types and complexions. The main difference lies in each product’s formulation, which can influence certain factors, such as how much is used and how quickly results can take effect.

· Botox® has an accompanying protein.

· Dysport® contains a lesser version of a similar protein.

· Xeomin® Deemed the “naked” injectable as it does not does not contain any accompanying proteins, pure Botulinum toxin A.


Which Work Faster – Botox®, Dysport® or Xeomin®?

The manufacturer of Dysport® asserts that its effects can be seen in about two to three days. The manufacturer of Xeomin® reports that it takes an average of three to four days for the initial effects to become noticeable, and up to one month to see the product’s full effects (though the vast majority have results by the 2 week mark). Most studies have supported that Dysport provides the fastest results, followed by Botox® and then Xeomin®.

All three provide about the same benefits which last for about three to four months on average, with some patients enjoying wrinkle-free results for up to six months before facial lines start to naturally reappear.

How Do Dosage and Diffusion Differ Between Botox®, Dysport® and Xeomin®?

According to the International Association for Physicians in Aesthetic Medicine (IAPAM), Botox® and Xeomin® are not interchangeable with Dysport® because the products are dosed differently. One unit of Botox® or Xeomin® is similar to three units of Dysport®. Thus 20 units of Botox® would equal 60 units of Dysport®.

IAPAM also reports that Dysport has been shown to diffuse more than Botox and Xeomin, which has the potential to carry its own benefits and risks. Since Dysport® has more diffusion, some doctors feel it can be better for treating crow’s feet because it of its even distribution. But it can also increase the risk of an accidental droopy eyelid or unintentional relaxation of a neighboring muscle due to its diffusion properties. However, this is extremely uncommon and can be avoided by using a licensed medical aesthetic professional who is highly trained on administering Botulinum toxin A injections.

Which is Best for You – Botox®, Dysport® or Xeomin®?

At Koniver Aesthetics, we offer each of the three current neurotoxins on the market. We find that contrary to popular belief, most of our patients notice little to no difference between the three options. However, for the percentage of patients who do notice a difference, they are very loyal to their respective brands.

Schedule a consultation to learn more about the subtle differences between Botox®, Dysport®, and Xeomin®, and let us help you determine which is the best option for you based on your own anti-aging treatment goals.